Assay Detail
Binding
CHEMBL662330
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Compound was evaluated for inhibition of amidolytic activity for chromogenic substrate Coagulation factor X
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.11 | 7.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344204 | — | — | 1 | 7.69 |
| CHEMBL141676 | — | — | 1 | 6.52 |
| CHEMBL141424 | — | — | 1 | - |
| CHEMBL138441 | — | — | 1 | - |
| CHEMBL342838 | — | — | 2 | - |
| CHEMBL342604 | — | — | 1 | - |
| CHEMBL342914 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344204 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL141676 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL141424 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL138441 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL342838 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL342838 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL342604 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL342914 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL342914 | — | IC50 | > | 25000.0 | nM | - |