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Assay Detail

CHEMBL662407

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards Cholecystokinin type A receptor from rat pancreas using [I125]-L-364,718 as the radioligand
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cholecystokinin receptor type A (CHEMBL2871)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and biological activity of 5-heteroaryl benzodiazepines: analogues of YM022
Semple G, Ryder H, Kendrick DA, Szelke M, Ohta M, Satoh M, Nishida A, Akuzawa S, Miyata K
Bioorg Med Chem Lett (1996) 6 : 55 -58
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.34 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL347843 1 7.10
CHEMBL345880 1 6.98
CHEMBL358646 1 6.96
CHEMBL345686 1 6.84
CHEMBL434126 1 6.63
CHEMBL435447 1 6.36
CHEMBL158235 1 6.33
CHEMBL538912 1 6.17
CHEMBL155627 1 6.07
CHEMBL152306 1 6.01
CHEMBL156484 1 5.87
CHEMBL352217 1 5.58
CHEMBL351144 1 5.58
CHEMBL350683 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL347843 IC50 = 80.0 nM 7.10
CHEMBL345880 IC50 = 105.0 nM 6.98
CHEMBL358646 IC50 = 111.0 nM 6.96
CHEMBL345686 IC50 = 146.0 nM 6.84
CHEMBL434126 IC50 = 232.0 nM 6.63
CHEMBL435447 IC50 = 433.0 nM 6.36
CHEMBL158235 IC50 = 470.0 nM 6.33
CHEMBL538912 IC50 = 670.0 nM 6.17
CHEMBL155627 IC50 = 844.0 nM 6.07
CHEMBL152306 IC50 = 980.0 nM 6.01
CHEMBL156484 IC50 = 1356.0 nM 5.87
CHEMBL352217 IC50 = 2615.0 nM 5.58
CHEMBL351144 IC50 = 2600.0 nM 5.58
CHEMBL350683 IC50 > 10000.0 nM -