Assay Detail
Binding
CHEMBL662414
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type A receptor in rat pancreatic membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Relationship between dihedral angles of N1 and C9 substituents in 1,4-benzodiazepines and dual cholecystokinin-A and -B antagonistic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.68 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32492 | — | — | 1 | 7.89 |
| CHEMBL285921 | — | — | 1 | 7.85 |
| CHEMBL285850 | — | — | 1 | 7.75 |
| CHEMBL432266 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32492 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL285921 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL285850 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL432266 | — | IC50 | = | 62.0 | nM | 7.21 |