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Assay Detail

CHEMBL662417

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of [125I]- Bolton Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cholecystokinin receptor type A (CHEMBL2871)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and sar study of novel CCK-B antagonists
Padia J, Bolton G, Hill D, Horell D, Roth B, Trivedi B
Bioorg Med Chem Lett (1993) 3 : 2805 -2810
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.04 7.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL356898 1 7.59
CHEMBL317675 1 6.73
CHEMBL433384 1 6.47
CHEMBL62205 1 6.42
CHEMBL317577 1 6.28
CHEMBL317626 1 6.25
CHEMBL96469 1 6.17
CHEMBL318963 1 5.97
CHEMBL2304063 1 5.73
CHEMBL96401 1 5.70
CHEMBL328213 1 5.63
CHEMBL94298 1 5.60
CHEMBL2062144 1 5.51
CHEMBL2304062 1 5.37
CHEMBL94352 1 5.20
CHEMBL317062 1 -
CHEMBL405208 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL356898 IC50 = 25.5 nM 7.59
CHEMBL317675 IC50 = 186.0 nM 6.73
CHEMBL433384 IC50 = 337.0 nM 6.47
CHEMBL62205 IC50 = 377.0 nM 6.42
CHEMBL317577 IC50 = 527.0 nM 6.28
CHEMBL317626 IC50 = 564.0 nM 6.25
CHEMBL96469 IC50 = 672.0 nM 6.17
CHEMBL318963 IC50 = 1079.0 nM 5.97
CHEMBL2304063 IC50 = 1846.0 nM 5.73
CHEMBL96401 IC50 = 1980.0 nM 5.70
CHEMBL328213 IC50 = 2330.0 nM 5.63
CHEMBL94298 IC50 = 2520.0 nM 5.60
CHEMBL2062144 IC50 = 3100.0 nM 5.51
CHEMBL2304062 IC50 = 4300.0 nM 5.37
CHEMBL94352 IC50 = 6320.0 nM 5.20
CHEMBL317062 IC50 > 1000.0 nM -
CHEMBL405208 IC50 > 1000.0 nM -