Assay Detail
Binding
CHEMBL662424
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Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type A receptor of rat pancreatic membranes.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Analogs of CCK incorporating conformationally constrained replacements for Asp32.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.55 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411079 | — | — | 1 | 10.30 |
| CHEMBL438773 | — | — | 1 | 9.22 |
| CHEMBL411202 | — | — | 1 | 8.85 |
| CHEMBL263155 | — | — | 1 | 8.62 |
| CHEMBL438911 | — | — | 1 | 8.26 |
| CHEMBL407530 | — | — | 1 | 8.08 |
| CHEMBL385727 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411079 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL438773 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL411202 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL263155 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL438911 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL407530 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL385727 | — | IC50 | = | 314.0 | nM | 6.50 |