Assay Detail
Binding
CHEMBL662426
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-antigastrin activity relationships of new (R)-4-benzamido-5-oxopentanoic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 5.04 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.30 |
| CHEMBL124832 | — | — | 1 | 7.52 |
| CHEMBL340263 | — | — | 1 | 7.30 |
| CHEMBL24938 | LORGLUMIDE | 2.0 | 1 | 7.30 |
| CHEMBL124509 | — | — | 1 | 6.52 |
| CHEMBL340630 | — | — | 1 | 6.40 |
| CHEMBL334171 | — | — | 1 | 6.40 |
| CHEMBL125925 | — | — | 1 | 6.22 |
| CHEMBL340463 | — | — | 1 | 5.89 |
| CHEMBL124732 | — | — | 1 | 5.89 |
| CHEMBL1328 | PENTAGASTRIN | 4.0 | 1 | 5.76 |
| CHEMBL339453 | — | — | 1 | 5.70 |
| CHEMBL339041 | — | — | 1 | 5.42 |
| CHEMBL123684 | — | — | 1 | 5.20 |
| CHEMBL124917 | — | — | 1 | 5.17 |
| CHEMBL331413 | — | — | 1 | 5.10 |
| CHEMBL124090 | — | — | 1 | 5.07 |
| CHEMBL339134 | — | — | 1 | 4.99 |
| CHEMBL2111826 | — | — | 1 | 4.98 |
| CHEMBL338929 | — | — | 1 | 4.96 |
| CHEMBL421438 | — | — | 1 | 4.96 |
| CHEMBL124261 | — | — | 1 | 4.90 |
| CHEMBL122922 | — | — | 1 | 4.89 |
| CHEMBL340413 | — | — | 1 | 4.87 |
| CHEMBL123720 | — | — | 1 | 4.85 |
| CHEMBL125551 | — | — | 1 | 4.73 |
| CHEMBL435587 | — | — | 1 | 4.72 |
| CHEMBL421474 | — | — | 1 | 4.68 |
| CHEMBL338134 | — | — | 1 | 4.65 |
| CHEMBL341143 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL124832 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL24938 | LORGLUMIDE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL340263 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL124509 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL340630 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL334171 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL125925 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL340463 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL124732 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1328 | PENTAGASTRIN | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL339453 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL339041 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL123684 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL124917 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL331413 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL124090 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL339134 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2111826 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL338929 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL421438 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL124261 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL122922 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL340413 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL123720 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL125551 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL435587 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL421474 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL338134 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL341143 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL123089 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL339115 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL124805 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL124155 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL125703 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL124764 | — | IC50 | = | 28900.0 | nM | 4.54 |
| CHEMBL127604 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL125874 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL124396 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL434250 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL2111827 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL2111828 | — | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL338045 | — | IC50 | = | 48200.0 | nM | 4.32 |
| CHEMBL124459 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL123785 | — | IC50 | = | 62500.0 | nM | 4.20 |
| CHEMBL2111825 | — | IC50 | = | 65800.0 | nM | 4.18 |
| CHEMBL124751 | — | IC50 | = | 66500.0 | nM | 4.18 |
| CHEMBL339707 | — | IC50 | = | 67500.0 | nM | 4.17 |
| CHEMBL341505 | — | IC50 | = | 72200.0 | nM | 4.14 |
| CHEMBL123852 | — | IC50 | = | 73500.0 | nM | 4.13 |