Assay Detail
Binding
CHEMBL662431
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Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type A receptor of rat pancreas
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The rational design and synthesis of non-peptide rhegnylogues of CCK-26-33 - a novel series of CCK-A selective ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.09 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 10.00 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 10.00 |
| CHEMBL319340 | — | — | 1 | 8.42 |
| CHEMBL9485 | — | — | 1 | 7.30 |
| CHEMBL169710 | — | — | 1 | 7.24 |
| CHEMBL278780 | — | — | 1 | 7.12 |
| CHEMBL355275 | — | — | 1 | 6.85 |
| CHEMBL355052 | — | — | 1 | 6.72 |
| CHEMBL170129 | — | — | 1 | 6.64 |
| CHEMBL355532 | — | — | 1 | 6.16 |
| CHEMBL171375 | — | — | 1 | 5.92 |
| CHEMBL352817 | — | — | 1 | 5.85 |
| CHEMBL171562 | — | — | 1 | 5.57 |
| CHEMBL434113 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL319340 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL9485 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL169710 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL278780 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL355275 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL355052 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL170129 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL355532 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL171375 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL352817 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL171562 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL434113 | — | IC50 | = | 3100.0 | nM | 5.51 |