Assay Detail
Binding
CHEMBL662432
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Concentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreas
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Methionine replacements in biologically active peptides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.18 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120632 | TETRAGASTRIN | -1.0 | 1 | 5.37 |
| CHEMBL2369769 | — | — | 1 | 5.09 |
| CHEMBL2369762 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120632 | TETRAGASTRIN | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL2369769 | — | IC50 | = | 8159.0 | nM | 5.09 |
| CHEMBL2369762 | — | IC50 | = | 8490.0 | nM | 5.07 |