Assay Detail
Binding
CHEMBL662444
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Binding affinity against human coagulation factor X
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 8.70 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL152859 | — | — | 1 | 11.00 |
| CHEMBL152854 | — | — | 1 | 10.89 |
| CHEMBL347846 | — | — | 1 | 10.82 |
| CHEMBL422688 | — | — | 1 | 10.70 |
| CHEMBL154512 | — | — | 1 | 10.40 |
| CHEMBL421808 | — | — | 1 | 10.39 |
| CHEMBL347931 | — | — | 1 | 10.22 |
| CHEMBL153611 | — | — | 1 | 9.82 |
| CHEMBL356016 | — | — | 1 | 9.80 |
| CHEMBL346834 | — | — | 1 | 9.54 |
| CHEMBL152276 | — | — | 1 | 9.34 |
| CHEMBL152274 | — | — | 1 | 9.10 |
| CHEMBL444074 | — | — | 1 | 8.89 |
| CHEMBL134736 | — | — | 1 | 8.57 |
| CHEMBL358834 | — | — | 1 | 7.96 |
| CHEMBL559015 | — | — | 1 | 6.82 |
| CHEMBL154680 | — | — | 1 | 6.44 |
| CHEMBL153946 | — | — | 1 | 6.42 |
| CHEMBL422351 | — | — | 1 | 6.32 |
| CHEMBL156775 | — | — | 1 | 6.05 |
| CHEMBL154504 | — | — | 1 | 6.04 |
| CHEMBL154572 | — | — | 1 | 5.80 |
| CHEMBL346686 | — | — | 1 | - |
| CHEMBL154322 | — | — | 1 | - |
| CHEMBL358835 | — | — | 1 | - |
| CHEMBL152281 | — | — | 1 | - |
| CHEMBL347307 | — | — | 1 | - |
| CHEMBL346857 | — | — | 1 | - |
| CHEMBL440733 | — | — | 1 | - |
| CHEMBL154238 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL152859 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL152854 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL347846 | — | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL422688 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL154512 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL421808 | — | Ki | = | 0.041 | nM | 10.39 |
| CHEMBL347931 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL153611 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL356016 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL346834 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL152276 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL152274 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL444074 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL134736 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL358834 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL559015 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL154680 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL153946 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL422351 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL156775 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL154504 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL154572 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL346686 | — | Ki | = | 0.009 | nM | - |
| CHEMBL154322 | — | Ki | = | 0.007 | nM | - |
| CHEMBL358835 | — | Ki | < | 5.0 | nM | - |
| CHEMBL152281 | — | Ki | < | 0.005 | nM | - |
| CHEMBL347307 | — | Ki | = | 0.005 | nM | - |
| CHEMBL346857 | — | Ki | = | 0.001 | nM | - |
| CHEMBL440733 | — | Ki | = | 0.008 | nM | - |
| CHEMBL154238 | — | Ki | = | 0.008 | nM | - |
| CHEMBL359132 | — | Ki | = | 0.009 | nM | - |