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Assay Detail

CHEMBL662445

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Binding
Binding affinity against Coagulation factor X
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs.
Jia ZJ, Wu Y, Huang W, Zhang P, Clizbe LA, Goldman EA, Sinha U, Arfsten AE, Edwards ST, Alphonso M, Hutchaleelaha A, Scarborough RM, Zhu BY.
Bioorg Med Chem Lett (2004) 14 : 1221 -1227
PubMed 14980670 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 8.83 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL279212 1 9.52
CHEMBL21125 1 9.30
CHEMBL20714 1 9.30
CHEMBL281175 1 9.10
CHEMBL279091 1 8.96
CHEMBL279287 1 8.96
CHEMBL20660 1 8.96
CHEMBL280696 1 8.85
CHEMBL277949 1 8.82
CHEMBL20604 1 8.77
CHEMBL20536 1 8.74
CHEMBL20832 1 8.74
CHEMBL21065 1 8.74
CHEMBL277679 1 8.72
CHEMBL20934 1 8.62
CHEMBL20766 1 8.62
CHEMBL20299 1 8.60
CHEMBL280947 1 8.55
CHEMBL20603 1 8.54
CHEMBL20561 1 8.49
CHEMBL21027 1 8.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL279212 Ki = 0.3 nM 9.52
CHEMBL21125 Ki = 0.5 nM 9.30
CHEMBL20714 Ki = 0.5 nM 9.30
CHEMBL281175 Ki = 0.8 nM 9.10
CHEMBL279091 Ki = 1.1 nM 8.96
CHEMBL279287 Ki = 1.1 nM 8.96
CHEMBL20660 Ki = 1.1 nM 8.96
CHEMBL280696 Ki = 1.4 nM 8.85
CHEMBL277949 Ki = 1.5 nM 8.82
CHEMBL20604 Ki = 1.7 nM 8.77
CHEMBL20536 Ki = 1.8 nM 8.74
CHEMBL20832 Ki = 1.8 nM 8.74
CHEMBL21065 Ki = 1.8 nM 8.74
CHEMBL277679 Ki = 1.9 nM 8.72
CHEMBL20934 Ki = 2.4 nM 8.62
CHEMBL20766 Ki = 2.4 nM 8.62
CHEMBL20299 Ki = 2.5 nM 8.60
CHEMBL280947 Ki = 2.8 nM 8.55
CHEMBL20603 Ki = 2.9 nM 8.54
CHEMBL20561 Ki = 3.2 nM 8.49
CHEMBL21027 Ki = 3.4 nM 8.47