Assay Detail
Functional
CHEMBL662466
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological properties of new constrained CCK-B antagonists: discrimination of two affinity states of the CCK-B receptor on transfected CHO cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.04 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062154 | CI-988 | 1.0 | 1 | 7.52 |
| CHEMBL338525 | — | — | 1 | 7.43 |
| CHEMBL9387 | L-365260 | — | 1 | 7.41 |
| CHEMBL337934 | — | — | 1 | 7.26 |
| CHEMBL337933 | — | — | 1 | 7.25 |
| CHEMBL435404 | — | — | 1 | 7.14 |
| CHEMBL338526 | — | — | 1 | 6.66 |
| CHEMBL338300 | — | — | 1 | 6.41 |
| CHEMBL406359 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062154 | CI-988 | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL338525 | — | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL9387 | L-365260 | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL337934 | — | IC50 | = | 55.5 | nM | 7.26 |
| CHEMBL337933 | — | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL435404 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL338526 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL338300 | — | IC50 | = | 389.0 | nM | 6.41 |
| CHEMBL406359 | — | IC50 | = | 507.0 | nM | 6.29 |