Assay Detail
Binding
CHEMBL662512
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In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Asteroidea |
| Cell Type | Oocyte |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.90 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23327 | PURVALANOLA | — | 1 | 8.40 |
| CHEMBL23254 | PURVALANOL B | — | 1 | 8.22 |
| CHEMBL26446 | — | — | 1 | 7.60 |
| CHEMBL286721 | AMINOPURVALANOL | — | 2 | 7.48 |
| CHEMBL282193 | — | — | 1 | 7.22 |
| CHEMBL24484 | — | — | 1 | 7.22 |
| CHEMBL23525 | — | — | 1 | 6.82 |
| CHEMBL282330 | — | — | 1 | 6.75 |
| CHEMBL26513 | — | — | 1 | 6.70 |
| CHEMBL286491 | — | — | 1 | 6.70 |
| CHEMBL26564 | — | — | 1 | 6.70 |
| CHEMBL280623 | — | — | 1 | 6.70 |
| CHEMBL23317 | — | — | 1 | 6.70 |
| CHEMBL422759 | — | — | 1 | 6.64 |
| CHEMBL281525 | — | — | 1 | 6.52 |
| CHEMBL284899 | — | — | 1 | 6.40 |
| CHEMBL25840 | — | — | 1 | 6.37 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.19 |
| CHEMBL280074 | OLOMOUCINE | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23327 | PURVALANOLA | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL23254 | PURVALANOL B | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL26446 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL286721 | AMINOPURVALANOL | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL286721 | AMINOPURVALANOL | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL24484 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL282193 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL23525 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL282330 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL26564 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL23317 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL26513 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL280623 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL286491 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL422759 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL281525 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL284899 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL25840 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL280074 | OLOMOUCINE | IC50 | = | 7000.0 | nM | 5.16 |