Assay Detail
Binding
CHEMBL662528
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Inhibition of cyclin-dependent kinase 2-cyclin A3 (CDK2)
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.98 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319467 | — | — | 1 | 8.27 |
| CHEMBL434217 | — | — | 1 | 8.15 |
| CHEMBL122489 | — | — | 1 | 7.25 |
| CHEMBL331123 | — | — | 1 | 7.16 |
| CHEMBL123156 | — | — | 1 | 7.00 |
| CHEMBL436560 | — | — | 1 | 6.89 |
| CHEMBL122620 | — | — | 1 | 6.70 |
| CHEMBL123337 | — | — | 1 | 6.70 |
| CHEMBL123368 | — | — | 1 | 6.68 |
| CHEMBL122850 | — | — | 1 | 6.52 |
| CHEMBL124436 | — | — | 1 | 6.52 |
| CHEMBL332198 | — | — | 1 | 6.40 |
| CHEMBL435999 | — | — | 1 | 6.19 |
| CHEMBL125091 | — | — | 1 | 6.10 |
| CHEMBL122264 | — | — | 1 | 6.01 |
| CHEMBL122365 | — | — | 1 | 5.92 |
| CHEMBL123242 | — | — | 1 | 5.77 |
| CHEMBL332550 | — | — | 1 | 5.77 |
| CHEMBL122040 | — | — | 1 | 5.75 |
| CHEMBL341273 | — | — | 1 | 5.64 |
| CHEMBL338355 | — | — | 1 | 5.55 |
| CHEMBL123140 | — | — | 1 | 5.55 |
| CHEMBL332540 | — | — | 1 | 5.37 |
| CHEMBL122900 | — | — | 1 | 5.30 |
| CHEMBL124059 | — | — | 1 | 5.30 |
| CHEMBL262367 | — | — | 1 | 5.17 |
| CHEMBL122032 | — | — | 1 | 4.92 |
| CHEMBL330894 | — | — | 1 | 4.28 |
| CHEMBL121655 | — | — | 1 | 4.20 |
| CHEMBL121941 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319467 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL434217 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL122489 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL331123 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL123156 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL436560 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL122620 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL123337 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL123368 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL122850 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL124436 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL332198 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL435999 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL125091 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL122264 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL122365 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL123242 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL332550 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL122040 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL341273 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL338355 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL123140 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL332540 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL122900 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL124059 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL262367 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL122032 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL330894 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL121655 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL121941 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL340813 | — | IC50 | = | 69000.0 | nM | 4.16 |