Assay Detail
Binding
CHEMBL662697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine cathepsin D
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.38 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296588 | PEPSTATIN | 2.0 | 1 | 7.55 |
| CHEMBL1790497 | DITEKIREN | 2.0 | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296588 | PEPSTATIN | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1790497 | DITEKIREN | IC50 | = | 6300.0 | nM | 5.20 |