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Assay Detail

CHEMBL662699

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against bovine cathepsin D
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cathepsin D (CHEMBL4106)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Renin inhibitors containing alpha-heteroatom amino acids as P2 residues.
Repine JT, Kaltenbronn JS, Doherty AM, Hamby JM, Himmelsbach RJ, Kornberg BE, Taylor MD, Lunney EA, Humblet C, Rapundalo ST.
J Med Chem (1992) 35 : 1032 -1042
PubMed 1552498 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.39 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL8896 1 8.00
CHEMBL266334 1 8.00
CHEMBL262712 1 7.98
CHEMBL8836 1 7.85
CHEMBL8477 1 7.71
CHEMBL441325 1 7.67
CHEMBL8665 1 7.66
CHEMBL245193 1 7.55
CHEMBL418519 1 7.22
CHEMBL266139 1 7.10
CHEMBL267955 1 6.88
CHEMBL406692 1 6.33
CHEMBL276553 1 6.16
CHEMBL276372 1 -
CHEMBL267277 1 -
CHEMBL267042 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL8896 IC50 = 10.0 nM 8.00
CHEMBL266334 IC50 = 10.0 nM 8.00
CHEMBL262712 IC50 = 10.5 nM 7.98
CHEMBL8836 IC50 = 14.0 nM 7.85
CHEMBL8477 IC50 = 19.4 nM 7.71
CHEMBL441325 IC50 = 21.2 nM 7.67
CHEMBL8665 IC50 = 22.0 nM 7.66
CHEMBL245193 IC50 = 28.1 nM 7.55
CHEMBL418519 IC50 = 60.4 nM 7.22
CHEMBL266139 IC50 = 80.1 nM 7.10
CHEMBL267955 IC50 = 131.0 nM 6.88
CHEMBL406692 IC50 = 470.0 nM 6.33
CHEMBL276553 IC50 = 698.5 nM 6.16
CHEMBL276372 IC50 > 10000.0 nM -
CHEMBL267277 IC50 > 10000.0 nM -
CHEMBL267042 IC50 > 10000.0 nM -