Assay Detail
Binding
CHEMBL662722
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In vitro inhibitory activity against human carbonic anhydrase I (hCAI)
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 6.03 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307939 | — | — | 1 | 7.89 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL75855 | — | — | 1 | 6.60 |
| CHEMBL94341 | — | — | 1 | 6.57 |
| CHEMBL317890 | — | — | 1 | 6.57 |
| CHEMBL319818 | — | — | 1 | 6.50 |
| CHEMBL540698 | — | — | 1 | 6.24 |
| CHEMBL94499 | — | — | 1 | 6.13 |
| CHEMBL305726 | — | — | 1 | 6.12 |
| CHEMBL74491 | — | — | 1 | 6.12 |
| CHEMBL97694 | — | — | 1 | 6.12 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.11 |
| CHEMBL265534 | — | — | 1 | 6.07 |
| CHEMBL77284 | — | — | 1 | 6.05 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL329956 | — | — | 1 | 6.03 |
| CHEMBL317743 | — | — | 1 | 6.03 |
| CHEMBL316779 | — | — | 1 | 6.02 |
| CHEMBL76563 | — | — | 1 | 6.01 |
| CHEMBL308631 | — | — | 1 | 6.01 |
| CHEMBL98120 | — | — | 1 | 6.00 |
| CHEMBL309592 | — | — | 1 | 5.97 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL313873 | — | — | 1 | 5.89 |
| CHEMBL97425 | — | — | 1 | 5.89 |
| CHEMBL75747 | — | — | 1 | 5.82 |
| CHEMBL76956 | — | — | 1 | 5.77 |
| CHEMBL97725 | — | — | 1 | 5.76 |
| CHEMBL94551 | — | — | 1 | 5.75 |
| CHEMBL75620 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307939 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL75855 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL94341 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL317890 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL319818 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL540698 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL94499 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL305726 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL74491 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL97694 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL265534 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL77284 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL329956 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL317743 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL316779 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL308631 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL76563 | — | Ki | = | 975.0 | nM | 6.01 |
| CHEMBL98120 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL309592 | — | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL313873 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL97425 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL75747 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL76956 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL97725 | — | Ki | = | 1750.0 | nM | 5.76 |
| CHEMBL94551 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL75620 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL94746 | — | Ki | = | 1960.0 | nM | 5.71 |
| CHEMBL76626 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL306118 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL77359 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 50000.0 | nM | 4.30 |