Assay Detail
Binding
CHEMBL662728
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Inhibitory effect on human carbonic anhydrase I
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.42 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109151 | — | — | 1 | 8.52 |
| CHEMBL108380 | — | — | 1 | 8.30 |
| CHEMBL111216 | — | — | 1 | 8.26 |
| CHEMBL108982 | — | — | 1 | 8.15 |
| CHEMBL281376 | — | — | 1 | 7.42 |
| CHEMBL108381 | — | — | 1 | 7.30 |
| CHEMBL320711 | — | — | 1 | 7.30 |
| CHEMBL326036 | — | — | 1 | 7.30 |
| CHEMBL326240 | — | — | 1 | 7.21 |
| CHEMBL419553 | — | — | 1 | 7.16 |
| CHEMBL23579 | — | — | 1 | 6.96 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 6.60 |
| CHEMBL108502 | — | — | 1 | 6.58 |
| CHEMBL111504 | — | — | 1 | 6.44 |
| CHEMBL322589 | — | — | 1 | 6.34 |
| CHEMBL109142 | — | — | 1 | 6.26 |
| CHEMBL111360 | — | — | 1 | 6.22 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.11 |
| CHEMBL419188 | — | — | 1 | 6.10 |
| CHEMBL108971 | — | — | 1 | 6.07 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL111336 | — | — | 1 | 6.05 |
| CHEMBL107989 | — | — | 1 | 6.02 |
| CHEMBL324906 | — | — | 1 | 6.01 |
| CHEMBL108389 | — | — | 1 | 6.00 |
| CHEMBL419006 | — | — | 1 | 5.89 |
| CHEMBL107722 | — | — | 1 | 5.82 |
| CHEMBL111245 | — | — | 1 | 5.46 |
| CHEMBL432626 | — | — | 1 | 5.43 |
| CHEMBL109153 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109151 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL108380 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL111216 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL108982 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL281376 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL108381 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL320711 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL326036 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL326240 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL419553 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL23579 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL108502 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL111504 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL322589 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL109142 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL111360 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL419188 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL108971 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL111336 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL107989 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL324906 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL108389 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL419006 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL107722 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL111245 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL432626 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL109153 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL111074 | — | Ki | = | 22500.0 | nM | 4.65 |
| CHEMBL325321 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL322581 | — | Ki | = | 35600.0 | nM | 4.45 |