Assay Detail
Functional
CHEMBL662771
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Tested in vitro for growth inhibitory activity against DC-3F (hamster lung) cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | DC3F |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
7-Silylcamptothecins (silatecans): A new family of camptothecin antitumor agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.05 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321859 | — | — | 1 | 9.54 |
| CHEMBL107547 | — | — | 1 | 9.14 |
| CHEMBL420481 | — | — | 1 | 8.70 |
| CHEMBL109032 | — | — | 1 | 8.60 |
| CHEMBL321208 | — | — | 1 | 8.54 |
| CHEMBL322789 | — | — | 1 | 8.38 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.22 |
| CHEMBL322959 | — | — | 1 | 8.19 |
| CHEMBL108562 | — | — | 1 | 8.17 |
| CHEMBL108601 | — | — | 1 | 8.16 |
| CHEMBL107934 | — | — | 1 | 8.09 |
| CHEMBL322525 | — | — | 1 | 7.85 |
| CHEMBL324430 | — | — | 1 | 6.59 |
| CHEMBL108809 | — | — | 1 | 6.43 |
| CHEMBL441077 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321859 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL107547 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL420481 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL109032 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL321208 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL322789 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL322959 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL108562 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL108601 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL107934 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL322525 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL324430 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL108809 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL441077 | — | IC50 | = | 663.0 | nM | 6.18 |