Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL108562

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccc(OC(C)=O)cc1c2[Si](C)(C)C
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL108562
Phase Preclinical
Structure Type MOL
InChI Key JNLCPABBAXSGBU-VWLOTQADSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

478.6
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H26N2O6Si
MW 478.58

Activity Summary

IC50 2 meas. best 8.57

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
HL-60
CHEMBL383
 IC50 8.57 8.57 2.7 1
DC3F
CHEMBL612702
 IC50 8.17 8.17 6.7 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
HL-60 IC50 = 2.7 nM 8.57 Tested in vitro for growth inhibitory activity against HL60 (human promyelocytic... -
DC3F IC50 = 6.7 nM 8.17 Tested in vitro for growth inhibitory activity against DC-3F (hamster lung) cell... -

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(97)10181-0 Unchecked 2
- 10.1016/S0960-894X(97)10181-0 HL-60 1
- 10.1016/S0960-894X(97)10181-0 833K 1
- 10.1016/S0960-894X(97)10181-0 DC3F 1

Data from ChEMBL 36 via Core Engine