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Assay Detail

CHEMBL662784

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Binding
Inhibitory activity against Clostridium histolyticum collagenase (ChC) was determined
ChEMBL ↗
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hathewaya histolytica
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Collagenase (CHEMBL2095216) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.
Scozzafava A, Supuran CT.
J Med Chem (2000) 43 : 3677 -3687
PubMed 11020282 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 64 6.61 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL432223 — — 1 8.30
CHEMBL123775 — — 1 8.30
CHEMBL306726 — — 1 8.30
CHEMBL340461 — — 1 8.30
CHEMBL332755 — — 1 8.30
CHEMBL293503 — — 1 8.30
CHEMBL122711 — — 1 8.22
CHEMBL123463 — — 1 8.22
CHEMBL262676 — — 1 8.22
CHEMBL331311 — — 1 8.10
CHEMBL304281 — — 1 8.00
CHEMBL330857 — — 1 8.00
CHEMBL122831 — — 1 7.96
CHEMBL122836 — — 1 7.96
CHEMBL55110 — — 1 7.92
CHEMBL123041 — — 1 7.92
CHEMBL122719 — — 1 7.89
CHEMBL441084 — — 1 7.89
CHEMBL331342 — — 1 7.89
CHEMBL311336 — — 1 7.77
CHEMBL450327 — — 1 7.72
CHEMBL293774 — — 1 7.70
CHEMBL316169 — — 1 7.70
CHEMBL332120 — — 1 7.68
CHEMBL440714 — — 1 7.66
CHEMBL122651 — — 1 7.62
CHEMBL82868 — — 1 7.57
CHEMBL120049 — — 1 7.42
CHEMBL332406 — — 1 7.40
CHEMBL331669 — — 1 7.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL432223 — Ki = 5.0 nM 8.30
CHEMBL293503 — Ki = 5.0 nM 8.30
CHEMBL332755 — Ki = 5.0 nM 8.30
CHEMBL340461 — Ki = 5.0 nM 8.30
CHEMBL123775 — Ki = 5.0 nM 8.30
CHEMBL306726 — Ki = 5.0 nM 8.30
CHEMBL122711 — Ki = 6.0 nM 8.22
CHEMBL123463 — Ki = 6.0 nM 8.22
CHEMBL262676 — Ki = 6.0 nM 8.22
CHEMBL331311 — Ki = 8.0 nM 8.10
CHEMBL304281 — Ki = 10.0 nM 8.00
CHEMBL330857 — Ki = 10.0 nM 8.00
CHEMBL122831 — Ki = 11.0 nM 7.96
CHEMBL122836 — Ki = 11.0 nM 7.96
CHEMBL55110 — Ki = 12.0 nM 7.92
CHEMBL123041 — Ki = 12.0 nM 7.92
CHEMBL122719 — Ki = 13.0 nM 7.89
CHEMBL441084 — Ki = 13.0 nM 7.89
CHEMBL331342 — Ki = 13.0 nM 7.89
CHEMBL311336 — Ki = 17.0 nM 7.77
CHEMBL450327 — Ki = 19.0 nM 7.72
CHEMBL293774 — Ki = 20.0 nM 7.70
CHEMBL316169 — Ki = 20.0 nM 7.70
CHEMBL332120 — Ki = 21.0 nM 7.68
CHEMBL440714 — Ki = 22.0 nM 7.66
CHEMBL122651 — Ki = 24.0 nM 7.62
CHEMBL82868 — Ki = 27.0 nM 7.57
CHEMBL120049 — Ki = 38.0 nM 7.42
CHEMBL332406 — Ki = 40.0 nM 7.40
CHEMBL331669 — Ki = 45.0 nM 7.35
CHEMBL123167 — Ki = 54.0 nM 7.27
CHEMBL123443 — Ki = 69.0 nM 7.16
CHEMBL333248 — Ki = 78.0 nM 7.11
CHEMBL332858 — Ki = 80.0 nM 7.10
CHEMBL332429 — Ki = 79.0 nM 7.10
CHEMBL123382 — Ki = 95.0 nM 7.02
CHEMBL121916 — Ki = 103.0 nM 6.99
CHEMBL83508 — Ki = 120.0 nM 6.92
CHEMBL333896 — Ki = 130.0 nM 6.89
CHEMBL122925 — Ki = 500.0 nM 6.30
CHEMBL332362 — Ki = 800.0 nM 6.10
CHEMBL333532 — Ki = 7000.0 nM 5.16
CHEMBL122950 — Ki = 13000.0 nM 4.89
CHEMBL123233 — Ki = 18000.0 nM 4.75
CHEMBL122868 — Ki = 20000.0 nM 4.70
CHEMBL331114 — Ki = 29000.0 nM 4.54
CHEMBL121592 — Ki = 32000.0 nM 4.50
CHEMBL121729 — Ki = 36000.0 nM 4.44
CHEMBL123064 — Ki = 39000.0 nM 4.41
CHEMBL123105 — Ki = 50000.0 nM 4.30