Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL662785

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against the Clostridium histolyticum collagenase (ChC)
ChEMBL ↗
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hathewaya histolytica
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Collagenase (CHEMBL2095216) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties.
Scozzafava A, Supuran CT.
J Med Chem (2000) 43 : 1858 -1865
PubMed 10794702 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 68 7.75 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL54054 — — 1 8.30
CHEMBL293503 — — 1 8.30
CHEMBL301977 — — 1 8.22
CHEMBL54535 — — 1 8.22
CHEMBL54436 — — 1 8.15
CHEMBL54904 — — 1 8.10
CHEMBL280017 — — 1 8.05
CHEMBL300362 — — 1 8.05
CHEMBL298822 — — 1 8.05
CHEMBL299023 — — 1 8.05
CHEMBL293305 — — 1 8.05
CHEMBL299600 — — 1 8.00
CHEMBL54697 — — 1 8.00
CHEMBL53051 — — 1 8.00
CHEMBL56025 — — 1 8.00
CHEMBL297488 — — 1 8.00
CHEMBL300807 — — 1 8.00
CHEMBL417749 — — 1 8.00
CHEMBL54915 — — 1 7.96
CHEMBL55110 — — 1 7.92
CHEMBL53044 — — 1 7.92
CHEMBL52531 — — 1 7.92
CHEMBL292657 — — 1 7.92
CHEMBL417200 — — 1 7.92
CHEMBL54965 — — 1 7.89
CHEMBL298606 — — 1 7.89
CHEMBL292431 — — 1 7.89
CHEMBL54483 — — 1 7.89
CHEMBL439931 — — 1 7.82
CHEMBL55236 — — 1 7.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL54054 — Ki = 5.0 nM 8.30
CHEMBL293503 — Ki = 5.0 nM 8.30
CHEMBL54535 — Ki = 6.0 nM 8.22
CHEMBL301977 — Ki = 6.0 nM 8.22
CHEMBL54436 — Ki = 7.0 nM 8.15
CHEMBL54904 — Ki = 8.0 nM 8.10
CHEMBL280017 — Ki = 9.0 nM 8.05
CHEMBL300362 — Ki = 9.0 nM 8.05
CHEMBL298822 — Ki = 9.0 nM 8.05
CHEMBL299023 — Ki = 9.0 nM 8.05
CHEMBL293305 — Ki = 9.0 nM 8.05
CHEMBL56025 — Ki = 10.0 nM 8.00
CHEMBL54697 — Ki = 10.0 nM 8.00
CHEMBL53051 — Ki = 10.0 nM 8.00
CHEMBL299600 — Ki = 10.0 nM 8.00
CHEMBL297488 — Ki = 10.0 nM 8.00
CHEMBL300807 — Ki = 10.0 nM 8.00
CHEMBL417749 — Ki = 10.0 nM 8.00
CHEMBL54915 — Ki = 11.0 nM 7.96
CHEMBL55110 — Ki = 12.0 nM 7.92
CHEMBL53044 — Ki = 12.0 nM 7.92
CHEMBL52531 — Ki = 12.0 nM 7.92
CHEMBL292657 — Ki = 12.0 nM 7.92
CHEMBL417200 — Ki = 12.0 nM 7.92
CHEMBL54483 — Ki = 13.0 nM 7.89
CHEMBL298606 — Ki = 13.0 nM 7.89
CHEMBL54965 — Ki = 13.0 nM 7.89
CHEMBL292431 — Ki = 13.0 nM 7.89
CHEMBL439931 — Ki = 15.0 nM 7.82
CHEMBL55236 — Ki = 15.0 nM 7.82
CHEMBL54621 — Ki = 15.0 nM 7.82
CHEMBL55154 — Ki = 15.0 nM 7.82
CHEMBL301786 — Ki = 16.0 nM 7.80
CHEMBL54617 — Ki = 16.0 nM 7.80
CHEMBL55984 — Ki = 17.0 nM 7.77
CHEMBL55744 — Ki = 18.0 nM 7.75
CHEMBL56498 — Ki = 18.0 nM 7.75
CHEMBL293357 — Ki = 18.0 nM 7.75
CHEMBL54501 — Ki = 18.0 nM 7.75
CHEMBL293528 — Ki = 19.0 nM 7.72
CHEMBL55521 — Ki = 20.0 nM 7.70
CHEMBL293774 — Ki = 20.0 nM 7.70
CHEMBL53847 — Ki = 20.0 nM 7.70
CHEMBL55522 — Ki = 21.0 nM 7.68
CHEMBL56065 — Ki = 21.0 nM 7.68
CHEMBL301085 — Ki = 23.0 nM 7.64
CHEMBL299091 — Ki = 24.0 nM 7.62
CHEMBL53116 — Ki = 24.0 nM 7.62
CHEMBL53009 — Ki = 28.0 nM 7.55
CHEMBL417757 — Ki = 29.0 nM 7.54