Assay Detail
Binding
CHEMBL662797
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Inhibition of human collagenase (MMP1)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design and synthesis of the cartilage protective agent (CPA, Ro32-3555)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.56 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74670 | — | — | 1 | 9.30 |
| CHEMBL73763 | — | — | 1 | 9.00 |
| CHEMBL439944 | — | — | 1 | 8.59 |
| CHEMBL306412 | — | — | 1 | 8.31 |
| CHEMBL307192 | — | — | 1 | 8.15 |
| CHEMBL305729 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74670 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL73763 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL439944 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL306412 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL307192 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL305729 | — | IC50 | = | 10.1 | nM | 8.00 |