Assay Detail
Binding
CHEMBL662806
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Evaluated for inhibitory activity against Human fibroblast collagenase (HFC)
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Relationship between structure and bioavailability in a series of hydroxamate based metalloprotease inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.50 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324947 | — | — | 1 | 9.00 |
| CHEMBL114458 | — | — | 1 | 9.00 |
| CHEMBL113894 | — | — | 1 | 8.70 |
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 8.70 |
| CHEMBL116676 | — | — | 1 | 8.70 |
| CHEMBL114094 | — | — | 1 | 8.70 |
| CHEMBL332250 | — | — | 1 | 8.52 |
| CHEMBL324140 | — | — | 1 | 8.52 |
| CHEMBL325214 | — | — | 1 | 8.52 |
| CHEMBL423876 | — | — | 1 | 8.52 |
| CHEMBL430704 | — | — | 1 | 8.52 |
| CHEMBL331355 | — | — | 1 | 8.40 |
| CHEMBL324023 | — | — | 1 | 8.40 |
| CHEMBL116507 | — | — | 1 | 8.30 |
| CHEMBL114665 | — | — | 1 | 8.30 |
| CHEMBL116972 | — | — | 1 | 8.30 |
| CHEMBL280271 | — | — | 1 | 8.22 |
| CHEMBL45483 | — | — | 1 | 8.22 |
| CHEMBL117220 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324947 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL114458 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL113894 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL19611 | ILOMASTAT | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL116676 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL114094 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL332250 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL324140 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL325214 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL423876 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL430704 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL331355 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL324023 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL116507 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL114665 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL116972 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL280271 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL45483 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL117220 | — | Ki | = | 12.0 | nM | 7.92 |