Assay Detail
Binding
CHEMBL662831
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against Coagulation factor X
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 4.79 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122331 | — | — | 1 | 5.36 |
| CHEMBL121982 | — | — | 1 | 5.12 |
| CHEMBL421437 | — | — | 1 | 5.08 |
| CHEMBL122801 | — | — | 1 | 5.00 |
| CHEMBL123759 | — | — | 1 | 4.85 |
| CHEMBL123142 | — | — | 1 | 4.80 |
| CHEMBL421272 | — | — | 1 | 4.57 |
| CHEMBL338788 | — | — | 1 | 4.28 |
| CHEMBL96486 | — | — | 1 | 4.03 |
| CHEMBL331181 | — | — | 1 | - |
| CHEMBL124408 | — | — | 1 | - |
| CHEMBL420334 | — | — | 1 | - |
| CHEMBL121661 | — | — | 1 | - |
| CHEMBL122432 | — | — | 1 | - |
| CHEMBL331160 | — | — | 1 | - |
| CHEMBL122601 | — | — | 1 | - |
| CHEMBL331908 | — | — | 1 | - |
| CHEMBL123942 | — | — | 1 | - |
| CHEMBL125181 | — | — | 1 | - |
| CHEMBL122488 | — | — | 1 | - |
| CHEMBL435012 | — | — | 1 | - |
| CHEMBL337923 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122331 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL121982 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL421437 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL122801 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL123759 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL123142 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL421272 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL338788 | — | Ki | = | 52000.0 | nM | 4.28 |
| CHEMBL96486 | — | Ki | = | 94000.0 | nM | 4.03 |
| CHEMBL331181 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL124408 | — | Ki | = | 230000.0 | nM | - |
| CHEMBL420334 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL121661 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL122432 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL331160 | — | Ki | = | 420000.0 | nM | - |
| CHEMBL122601 | — | Ki | = | 240000.0 | nM | - |
| CHEMBL331908 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL123942 | — | Ki | = | 160000.0 | nM | - |
| CHEMBL125181 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL122488 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL435012 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL337923 | — | Ki | = | 160000.0 | nM | - |