Assay Detail
Binding
CHEMBL662841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Cytochrome P450 17A1 (17-alpha-hydroxypregnenolone Km=560 nM)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.16 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74661 | — | — | 1 | 8.92 |
| CHEMBL78108 | — | — | 1 | 8.85 |
| CHEMBL310336 | — | — | 1 | 8.72 |
| CHEMBL310822 | — | — | 1 | 7.64 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 7.42 |
| CHEMBL307729 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74661 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL78108 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL310336 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL310822 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL157101 | KETOCONAZOLE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL307729 | — | Ki | = | 41.0 | nM | 7.39 |