Assay Detail
Binding
CHEMBL662843
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat testicual microsomal Cytochrome P450 17A1
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL4430) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.82 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419743 | — | — | 1 | 5.82 |
| CHEMBL2112522 | — | — | 1 | 5.82 |
| CHEMBL114864 | — | — | 1 | 5.82 |
| CHEMBL115944 | — | — | 1 | 5.82 |
| CHEMBL113205 | — | — | 1 | 5.82 |
| CHEMBL419934 | — | — | 1 | 5.82 |
| CHEMBL325895 | — | — | 1 | 5.82 |
| CHEMBL2112528 | — | — | 1 | 5.82 |
| CHEMBL333604 | — | — | 1 | 5.82 |
| CHEMBL2112534 | — | — | 1 | 5.82 |
| CHEMBL541717 | — | — | 1 | 5.82 |
| CHEMBL113804 | — | — | 1 | 5.82 |
| CHEMBL113407 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419743 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2112522 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL114864 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL115944 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL113205 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL419934 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL325895 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2112528 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL333604 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2112534 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL541717 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL113804 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL113407 | — | IC50 | = | 1500.0 | nM | 5.82 |