Assay Detail
Binding
CHEMBL662844
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In vitro inhibitory activity against Steroidgenic Cytochrome P450 17 alpha using rat testicular microsomes.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL4430) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.33 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169086 | — | — | 1 | 4.68 |
| CHEMBL168434 | — | — | 1 | 4.51 |
| CHEMBL304903 | — | — | 1 | 4.44 |
| CHEMBL90585 | — | — | 1 | 4.43 |
| CHEMBL168636 | — | — | 1 | 4.32 |
| CHEMBL169251 | — | — | 1 | 4.13 |
| CHEMBL440930 | — | — | 1 | 4.06 |
| CHEMBL352645 | — | — | 1 | 4.05 |
| CHEMBL424556 | — | — | 1 | - |
| CHEMBL433728 | — | — | 1 | - |
| CHEMBL169449 | — | — | 1 | - |
| CHEMBL166789 | — | — | 1 | - |
| CHEMBL415753 | — | — | 1 | - |
| CHEMBL169664 | — | — | 1 | - |
| CHEMBL168762 | — | — | 1 | - |
| CHEMBL168444 | — | — | 1 | - |
| CHEMBL168700 | — | — | 1 | - |
| CHEMBL424203 | — | — | 1 | - |
| CHEMBL28689 | — | — | 1 | - |
| CHEMBL166709 | — | — | 1 | - |
| CHEMBL166974 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169086 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL168434 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL304903 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL90585 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL168636 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL169251 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL440930 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL352645 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL424556 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL433728 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL169449 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL166789 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL415753 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL169664 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL168762 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL168444 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL168700 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL424203 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL28689 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL166709 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL166974 | — | IC50 | < | 10000.0 | nM | - |