Assay Detail
Binding
CHEMBL662845
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Inhibition of rat testicular microsomal Cytochrome P450 17A1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL4430) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.83 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325307 | — | — | 1 | 7.85 |
| CHEMBL2112517 | — | — | 1 | 7.55 |
| CHEMBL78215 | — | — | 1 | 7.50 |
| CHEMBL2112526 | — | — | 1 | 7.31 |
| CHEMBL113448 | — | — | 1 | 7.12 |
| CHEMBL113966 | — | — | 1 | 7.10 |
| CHEMBL2112521 | — | — | 1 | 7.08 |
| CHEMBL2112518 | — | — | 1 | 7.04 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.97 |
| CHEMBL2112533 | — | — | 1 | 5.32 |
| CHEMBL2112524 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325307 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2112517 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL78215 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2112526 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL113448 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL113966 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL2112521 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL2112518 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 1067.0 | nM | 5.97 |
| CHEMBL2112533 | — | IC50 | = | 4813.0 | nM | 5.32 |
| CHEMBL2112524 | — | IC50 | = | 5456.0 | nM | 5.26 |