Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL662870

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against serine protease Coagulation factor X
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors.
Becker MR, Ewing WR, Davis RS, Pauls HW, Ly C, Li A, Mason HJ, Choi-Sledeski YM, Spada AP, Chu V, Brown KD, Colussi DJ, Leadley RJ, Bentley R, Bostwick J, Kasiewski C, Morgan S.
Bioorg Med Chem Lett (1999) 9 : 2753 -2758
PubMed 10509929 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.93 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL92530 1 8.70
CHEMBL93854 1 8.52
CHEMBL418958 1 7.44
CHEMBL327600 1 7.33
CHEMBL421367 1 7.05
CHEMBL330582 1 6.92
CHEMBL93681 1 6.92
CHEMBL93796 1 6.64
CHEMBL92893 1 6.62
CHEMBL92345 1 6.42
CHEMBL93741 1 6.38
CHEMBL93431 1 6.32
CHEMBL93740 1 6.31
CHEMBL327636 1 6.29
CHEMBL93190 1 6.14
CHEMBL330493 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL92530 Ki = 2.0 nM 8.70
CHEMBL93854 Ki = 3.0 nM 8.52
CHEMBL418958 Ki = 36.0 nM 7.44
CHEMBL327600 Ki = 47.0 nM 7.33
CHEMBL421367 Ki = 90.0 nM 7.05
CHEMBL330582 Ki = 120.0 nM 6.92
CHEMBL93681 Ki = 120.0 nM 6.92
CHEMBL93796 Ki = 230.0 nM 6.64
CHEMBL92893 Ki = 240.0 nM 6.62
CHEMBL92345 Ki = 380.0 nM 6.42
CHEMBL93741 Ki = 420.0 nM 6.38
CHEMBL93431 Ki = 480.0 nM 6.32
CHEMBL93740 Ki = 490.0 nM 6.31
CHEMBL327636 Ki = 510.0 nM 6.29
CHEMBL93190 Ki = 720.0 nM 6.14
CHEMBL330493 Ki ~ 75.0 nM -