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Assay Detail

CHEMBL662874

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Binding
Binding affinity was evaluated against Coagulation factor X
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor XA inhibitors.
Mohan R, Yun W, Buckman BO, Liang A, Trinh L, Morrissey MM.
Bioorg Med Chem Lett (1998) 8 : 1877 -1882
PubMed 9873451 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 7.15 8.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL294703 1 8.17
CHEMBL55035 1 7.89
CHEMBL49636 1 7.89
CHEMBL20936 BENZAMIDINE 1 6.39
CHEMBL56410 1 6.30
CHEMBL417750 1 6.25
CHEMBL442554 1 -
CHEMBL300796 1 -
CHEMBL55828 1 -
CHEMBL55855 1 -
CHEMBL301057 1 -
CHEMBL55766 1 -
CHEMBL54676 1 -
CHEMBL55575 1 -
CHEMBL54672 1 -
CHEMBL433274 1 -
CHEMBL293108 1 -
CHEMBL54615 1 -
CHEMBL292203 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL294703 Ki = 6.8 nM 8.17
CHEMBL55035 Ki = 13.0 nM 7.89
CHEMBL49636 Ki = 13.0 nM 7.89
CHEMBL20936 BENZAMIDINE Ki = 410.0 nM 6.39
CHEMBL56410 Ki = 495.0 nM 6.30
CHEMBL417750 Ki = 560.0 nM 6.25
CHEMBL442554 Ki > 5000.0 nM -
CHEMBL300796 Ki > 5000.0 nM -
CHEMBL55828 Ki > 5000.0 nM -
CHEMBL55855 Ki > 5000.0 nM -
CHEMBL301057 Ki > 5000.0 nM -
CHEMBL55766 Ki > 5000.0 nM -
CHEMBL54676 Ki > 5000.0 nM -
CHEMBL55575 Ki > 5000.0 nM -
CHEMBL54672 Ki > 5000.0 nM -
CHEMBL433274 Ki > 5000.0 nM -
CHEMBL293108 Ki > 5000.0 nM -
CHEMBL54615 Ki > 5000.0 nM -
CHEMBL292203 Ki > 5000.0 nM -