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Assay Detail

CHEMBL662878

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Binding
Compound was evaluated for the inhibitory activity against Coagulation factor X
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Nonbenzamidine compounds as selective factor Xa inhibitors.
He W, Hanney B, Myers MR, Spada AP, Brown K, Colussi D, Chu V.
Bioorg Med Chem Lett (2000) 10 : 1737 -1739
PubMed 10937736 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 6.96 8.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL48813 1 8.89
CHEMBL48236 1 7.92
CHEMBL49510 1 7.68
CHEMBL295802 1 7.23
CHEMBL298374 1 7.01
CHEMBL47654 1 6.85
CHEMBL299614 1 6.85
CHEMBL45995 1 6.80
CHEMBL45585 1 6.77
CHEMBL46314 1 6.60
CHEMBL296218 1 6.57
CHEMBL46041 1 6.47
CHEMBL49509 1 6.37
CHEMBL299825 1 6.21
CHEMBL295515 1 6.21
CHEMBL297152 1 -
CHEMBL46147 1 -
CHEMBL45616 1 -
CHEMBL48437 1 -
CHEMBL301945 1 -
CHEMBL296681 1 -
CHEMBL50757 1 -
CHEMBL295046 1 -
CHEMBL298749 1 -
CHEMBL45839 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL48813 Ki = 1.3 nM 8.89
CHEMBL48236 Ki = 12.0 nM 7.92
CHEMBL49510 Ki = 21.0 nM 7.68
CHEMBL295802 Ki = 59.0 nM 7.23
CHEMBL298374 Ki = 97.0 nM 7.01
CHEMBL47654 Ki = 140.0 nM 6.85
CHEMBL299614 Ki = 140.0 nM 6.85
CHEMBL45995 Ki = 160.0 nM 6.80
CHEMBL45585 Ki = 170.0 nM 6.77
CHEMBL46314 Ki = 250.0 nM 6.60
CHEMBL296218 Ki = 270.0 nM 6.57
CHEMBL46041 Ki = 340.0 nM 6.47
CHEMBL49509 Ki = 430.0 nM 6.37
CHEMBL299825 Ki = 620.0 nM 6.21
CHEMBL295515 Ki = 620.0 nM 6.21
CHEMBL297152 Ki > 1200.0 nM -
CHEMBL46147 Ki > 1200.0 nM -
CHEMBL45616 Ki > 1200.0 nM -
CHEMBL48437 Ki > 1200.0 nM -
CHEMBL301945 Ki > 1200.0 nM -
CHEMBL296681 Ki > 1200.0 nM -
CHEMBL50757 Ki > 1200.0 nM -
CHEMBL295046 Ki > 1200.0 nM -
CHEMBL298749 Ki > 1200.0 nM -
CHEMBL45839 Ki > 1200.0 nM -