Assay Detail
Binding
CHEMBL662880
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In vitro binding affinity towards factor Xa
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.14 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352039 | — | — | 1 | 10.89 |
| CHEMBL423810 | — | — | 1 | 9.77 |
| CHEMBL350587 | — | — | 1 | 8.89 |
| CHEMBL162461 | — | — | 1 | 8.85 |
| CHEMBL159695 | — | — | 1 | 8.64 |
| CHEMBL163174 | — | — | 1 | 8.57 |
| CHEMBL355376 | — | — | 1 | 8.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352039 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL423810 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL350587 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL162461 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL159695 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL163174 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL355376 | — | Ki | = | 4.4 | nM | 8.36 |