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Assay Detail

CHEMBL663034

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against coagulation factor VIIa
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Coagulation factor VII (CHEMBL3991)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Secondary structure peptide mimetics: design, synthesis, and evaluation of beta-strand mimetic thrombin inhibitors.
Boatman PD, Ogbu CO, Eguchi M, Kim HO, Nakanishi H, Cao B, Shea JP, Kahn M.
J Med Chem (1999) 42 : 1367 -1375
PubMed 10212122 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 6.64 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL27852 1 6.70
CHEMBL282830 1 6.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL27852 IC50 = 200.0 nM 6.70
CHEMBL282830 IC50 = 270.0 nM 6.57