Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL663091

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Gastrin/cholecystokinin type B receptor (CHEMBL298)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Cholecystokinin peptidomimetics as selective CCK-B antagonists: design, synthesis, and in vitro and in vivo biochemical properties.
Blommaert AG, Weng JH, Dorville A, McCort I, Ducos B, Durieux C, Roques BP.
J Med Chem (1993) 36 : 2868 -2877
PubMed 8411002 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 26 6.94 8.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99939 2 8.21
CHEMBL318852 1 7.91
CHEMBL317999 1 7.85
CHEMBL319120 1 7.57
CHEMBL330390 1 7.44
CHEMBL319880 1 7.43
CHEMBL433407 1 7.41
CHEMBL320399 1 7.30
CHEMBL432389 1 7.29
CHEMBL328852 1 7.10
CHEMBL291033 1 7.06
CHEMBL319085 1 7.06
CHEMBL329088 1 6.94
CHEMBL98516 1 6.87
CHEMBL316462 1 6.74
CHEMBL95793 1 6.74
CHEMBL95461 1 6.65
CHEMBL99076 1 6.64
CHEMBL95689 1 6.40
CHEMBL318238 1 6.39
CHEMBL320823 1 6.26
CHEMBL96036 1 6.01
CHEMBL99065 1 5.46
CHEMBL276676 1 4.68
CHEMBL319096 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99939 Ki = 6.1 nM 8.21
CHEMBL99939 Ki = 6.5 nM 8.19
CHEMBL318852 Ki = 12.3 nM 7.91
CHEMBL317999 Ki = 14.0 nM 7.85
CHEMBL319120 Ki = 27.0 nM 7.57
CHEMBL330390 Ki = 36.0 nM 7.44
CHEMBL319880 Ki = 36.8 nM 7.43
CHEMBL433407 Ki = 39.0 nM 7.41
CHEMBL320399 Ki = 50.0 nM 7.30
CHEMBL432389 Ki = 51.0 nM 7.29
CHEMBL328852 Ki = 79.0 nM 7.10
CHEMBL291033 Ki = 87.0 nM 7.06
CHEMBL319085 Ki = 87.0 nM 7.06
CHEMBL329088 Ki = 115.0 nM 6.94
CHEMBL98516 Ki = 134.0 nM 6.87
CHEMBL95793 Ki = 182.0 nM 6.74
CHEMBL316462 Ki = 184.0 nM 6.74
CHEMBL95461 Ki = 224.0 nM 6.65
CHEMBL99076 Ki = 231.0 nM 6.64
CHEMBL95689 Ki = 402.0 nM 6.40
CHEMBL318238 Ki = 407.0 nM 6.39
CHEMBL320823 Ki = 543.0 nM 6.26
CHEMBL96036 Ki = 986.0 nM 6.01
CHEMBL99065 Ki = 3478.0 nM 5.46
CHEMBL276676 Ki = 20968.0 nM 4.68
CHEMBL319096 Ki > 0.0001 nM -