Assay Detail
Binding
CHEMBL663103
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Potency to displace the specific in vitro binding of [3H]N-0437 to calf striatal membrane
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.79 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38428 | — | — | 1 | 8.10 |
| CHEMBL69271 | NAXAGOLIDE | 2.0 | 1 | 7.89 |
| CHEMBL607437 | — | — | 1 | 7.62 |
| CHEMBL285755 | — | — | 1 | 7.20 |
| CHEMBL69414 | — | — | 1 | 5.85 |
| CHEMBL70565 | — | — | 1 | 5.80 |
| CHEMBL607438 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38428 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL69271 | NAXAGOLIDE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL607437 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL285755 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL69414 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL70565 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL607438 | — | IC50 | = | 8900.0 | nM | 5.05 |