Assay Detail
Binding
CHEMBL663174
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Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL2854) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.67 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138534 | — | — | 1 | 9.82 |
| CHEMBL2062154 | CI-988 | 1.0 | 1 | 8.77 |
| CHEMBL353157 | — | — | 1 | 8.38 |
| CHEMBL141630 | — | — | 1 | 8.03 |
| CHEMBL145133 | — | — | 1 | 7.88 |
| CHEMBL355656 | — | — | 1 | 7.64 |
| CHEMBL263969 | — | — | 1 | 7.37 |
| CHEMBL2062144 | — | — | 1 | 7.20 |
| CHEMBL169615 | — | — | 1 | 6.80 |
| CHEMBL169616 | — | — | 1 | 6.77 |
| CHEMBL171806 | — | — | 1 | 6.75 |
| CHEMBL356898 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138534 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL2062154 | CI-988 | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL353157 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL141630 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL145133 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL355656 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL263969 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2062144 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL169615 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL169616 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL171806 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL356898 | — | IC50 | = | 259.0 | nM | 6.59 |