Assay Detail
Binding
CHEMBL663210
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In vitro inhibitory activity against Cysteinyl leukotriene D4 receptor from human lung membrane
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Lung |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl] [[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.31 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89768 | — | — | 1 | 8.51 |
| CHEMBL280481 | VERLUKAST | 2.0 | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89768 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL280481 | VERLUKAST | IC50 | = | 8.0 | nM | 8.10 |