Assay Detail
Binding
CHEMBL663215
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Binding affinity against Cysteinyl leukotriene D4 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Modulators of leukotriene biosynthesis and receptor activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.48 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89768 | — | — | 1 | 9.70 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 1 | 9.52 |
| CHEMBL18518 | RG-12525 | — | 1 | 8.52 |
| CHEMBL22776 | POBILUKAST | 2.0 | 1 | 8.30 |
| CHEMBL315802 | — | — | 1 | 7.58 |
| CHEMBL17344 | RITOLUKAST | 2.0 | 1 | 7.46 |
| CHEMBL21595 | — | — | 1 | 7.22 |
| CHEMBL21247 | L-649923 | — | 1 | 6.40 |
| CHEMBL162358 | TOMELUKAST | 2.0 | 1 | 6.22 |
| CHEMBL8747 | REV-5901 | — | 1 | 6.16 |
| CHEMBL282253 | L-648051 | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89768 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL603 | ZAFIRLUKAST | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL18518 | RG-12525 | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL22776 | POBILUKAST | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL315802 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL17344 | RITOLUKAST | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL21595 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL21247 | L-649923 | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL162358 | TOMELUKAST | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL8747 | REV-5901 | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL282253 | L-648051 | Ki | = | 6200.0 | nM | 5.21 |