Assay Detail
Binding
CHEMBL663267
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Binding affinity to purified human coagulation factor Xa (FXa)
28
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.90 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1202108 | — | — | 1 | 10.40 |
| CHEMBL327404 | — | — | 4 | 9.08 |
| CHEMBL327213 | — | — | 4 | 8.64 |
| CHEMBL279628 | — | — | 4 | 8.41 |
| CHEMBL72514 | — | — | 1 | 8.38 |
| CHEMBL408928 | — | — | 1 | 8.38 |
| CHEMBL328239 | — | — | 1 | 8.06 |
| CHEMBL321314 | — | — | 1 | 7.72 |
| CHEMBL319206 | — | — | 1 | 7.55 |
| CHEMBL329568 | — | — | 1 | 7.28 |
| CHEMBL327430 | — | — | 1 | 7.21 |
| CHEMBL93227 | — | — | 1 | 7.18 |
| CHEMBL433369 | — | — | 1 | 7.17 |
| CHEMBL92988 | — | — | 1 | 7.03 |
| CHEMBL316349 | — | — | 1 | 6.70 |
| CHEMBL92519 | — | — | 1 | 6.68 |
| CHEMBL91796 | — | — | 1 | 6.66 |
| CHEMBL93536 | — | — | 1 | 6.62 |
| CHEMBL264628 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1202108 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL327404 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL327404 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL327404 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL327213 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL279628 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL72514 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL408928 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL327213 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL327213 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL279628 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL279628 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL279628 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL327404 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL328239 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL327213 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL321314 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL319206 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL329568 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL327430 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL93227 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL433369 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL92988 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL316349 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL92519 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL91796 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL93536 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL264628 | — | Ki | = | 240.0 | nM | 6.62 |