Assay Detail
Binding
CHEMBL663300
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for inhibition of specific [3H]propionyl-CCK-8 binding to Cholecystokinin type A receptor in rat pancreatic membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met28-Gly29.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.13 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331408 | — | — | 1 | 8.68 |
| CHEMBL122438 | — | — | 1 | 7.60 |
| CHEMBL405805 | — | — | 1 | 7.14 |
| CHEMBL2112635 | — | — | 1 | 6.79 |
| CHEMBL2111823 | — | — | 1 | 6.78 |
| CHEMBL126008 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331408 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL122438 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL405805 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2112635 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL2111823 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL126008 | — | IC50 | = | 1600.0 | nM | 5.80 |