Assay Detail
Binding
CHEMBL663301
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The compound was tested in vitro for inhibition of specific [3H]propionyl-CCK-8 binding to cholecystokinin type A receptor in rat pancreatic membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cholecystokinin receptor type A (CHEMBL2871) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met28-Gly29.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.09 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267849 | — | — | 1 | 9.22 |
| CHEMBL433647 | — | — | 1 | 8.31 |
| CHEMBL421471 | — | — | 1 | 7.66 |
| CHEMBL436199 | — | — | 1 | 6.44 |
| CHEMBL338056 | — | — | 1 | 5.92 |
| CHEMBL124719 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267849 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL433647 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL421471 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL436199 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL338056 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL124719 | — | IC50 | = | 10000.0 | nM | 5.00 |