Assay Detail
Binding
CHEMBL663316
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Inhibition of cathepsin K
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.02 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113724 | — | — | 1 | 9.30 |
| CHEMBL100563 | — | — | 1 | 8.64 |
| CHEMBL118449 | — | — | 1 | 8.59 |
| CHEMBL119285 | — | — | 1 | 8.46 |
| CHEMBL281540 | — | — | 1 | 7.66 |
| CHEMBL432634 | — | — | 1 | 7.60 |
| CHEMBL119219 | — | — | 1 | 7.52 |
| CHEMBL404801 | — | — | 1 | 7.25 |
| CHEMBL117054 | — | — | 1 | 6.05 |
| CHEMBL267064 | — | — | 1 | 5.46 |
| CHEMBL118347 | — | — | 1 | 5.09 |
| CHEMBL117790 | — | — | 1 | 4.82 |
| CHEMBL325379 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113724 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL100563 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL118449 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL119285 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL281540 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL432634 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL119219 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL404801 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL117054 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL267064 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL118347 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL117790 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL325379 | — | Ki | = | 16000.0 | nM | 4.80 |