Assay Detail
Binding
CHEMBL663318
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In vitro inhibition of human Cathepsin K.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cyclic ketone inhibitors of the cysteine protease cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.64 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348842 | — | — | 1 | 9.22 |
| CHEMBL350591 | — | — | 1 | 8.80 |
| CHEMBL162175 | — | — | 1 | 8.72 |
| CHEMBL100563 | — | — | 1 | 8.64 |
| CHEMBL118449 | — | — | 1 | 8.59 |
| CHEMBL62239 | — | — | 1 | 7.36 |
| CHEMBL301683 | — | — | 1 | 7.22 |
| CHEMBL2371402 | — | — | 1 | 7.11 |
| CHEMBL61805 | — | — | 1 | 6.85 |
| CHEMBL162631 | — | — | 1 | 6.82 |
| CHEMBL423995 | — | — | 1 | 6.75 |
| CHEMBL163592 | — | — | 1 | 6.64 |
| CHEMBL349445 | — | — | 1 | 6.60 |
| CHEMBL349823 | — | — | 1 | - |
| CHEMBL436437 | — | — | 1 | - |
| CHEMBL162389 | — | — | 1 | - |
| CHEMBL161964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348842 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL350591 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL162175 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL100563 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL118449 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL62239 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL301683 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL2371402 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL61805 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL162631 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL423995 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL163592 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL349445 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL349823 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL436437 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL162389 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL161964 | — | Ki | > | 1000.0 | nM | - |