Assay Detail
Binding
CHEMBL663327
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Inhibition of cysteine protease cathepsin K of rat
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design of potent, selective, and orally bioavailable inhibitors of cysteine protease cathepsin k.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.61 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154579 | — | — | 1 | 8.74 |
| CHEMBL154959 | — | — | 1 | 8.26 |
| CHEMBL156764 | — | — | 1 | 7.96 |
| CHEMBL345982 | — | — | 1 | 7.92 |
| CHEMBL154862 | — | — | 1 | 7.89 |
| CHEMBL157911 | — | — | 1 | 6.33 |
| CHEMBL345356 | — | — | 1 | 6.10 |
| CHEMBL157224 | — | — | 1 | 6.00 |
| CHEMBL155148 | — | — | 1 | 5.96 |
| CHEMBL155123 | — | — | 1 | 5.96 |
| CHEMBL155297 | — | — | 1 | 5.92 |
| CHEMBL345136 | — | — | 1 | 5.82 |
| CHEMBL155183 | — | — | 1 | 5.80 |
| CHEMBL152633 | — | — | 1 | 5.77 |
| CHEMBL155592 | — | — | 1 | 5.77 |
| CHEMBL346739 | — | — | 1 | 5.57 |
| CHEMBL346102 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154579 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL154959 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL156764 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL345982 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL154862 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL157911 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL345356 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL157224 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL155148 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL155123 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL155297 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL345136 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL155183 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL152633 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL155592 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL346739 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL346102 | — | IC50 | > | 1200.0 | nM | - |