Assay Detail
Binding
CHEMBL663365
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Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
6-Acylamino-penam derivatives: synthesis and inhibition of cathepsins B, L, K, and S.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.55 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114410 | — | — | 1 | 9.15 |
| CHEMBL326093 | — | — | 1 | 8.85 |
| CHEMBL117928 | — | — | 1 | 8.77 |
| CHEMBL323638 | — | — | 1 | 8.52 |
| CHEMBL116041 | — | — | 1 | 8.52 |
| CHEMBL113706 | — | — | 1 | 8.52 |
| CHEMBL323637 | — | — | 1 | 8.02 |
| CHEMBL326342 | — | — | 1 | 7.17 |
| CHEMBL332025 | — | — | 1 | 5.40 |
| CHEMBL421054 | — | — | 1 | 5.17 |
| CHEMBL323704 | — | — | 1 | 4.97 |
| CHEMBL115822 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114410 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL326093 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL117928 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL323638 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL116041 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL113706 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL323637 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL326342 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL332025 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL421054 | — | IC50 | = | 6680.0 | nM | 5.17 |
| CHEMBL323704 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL115822 | — | IC50 | > | 50000.0 | nM | - |