Assay Detail
Binding
CHEMBL663402
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Inhibition of Cyclin-dependent kinase 1-cyclin B
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.15 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310840 | — | — | 1 | 8.22 |
| CHEMBL310567 | — | — | 1 | 8.15 |
| CHEMBL81211 | — | — | 1 | 7.89 |
| CHEMBL309925 | — | — | 1 | 7.77 |
| CHEMBL78200 | — | — | 1 | 7.50 |
| CHEMBL79049 | — | — | 1 | 7.04 |
| CHEMBL14619 | SQ-67563 | — | 1 | 6.82 |
| CHEMBL82243 | — | — | 1 | 6.64 |
| CHEMBL312657 | — | — | 1 | 6.55 |
| CHEMBL79452 | — | — | 1 | 6.44 |
| CHEMBL81771 | — | — | 1 | 6.39 |
| CHEMBL78959 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310840 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL310567 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL81211 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL309925 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL78200 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL79049 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL14619 | SQ-67563 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL82243 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL312657 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL79452 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL81771 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL78959 | — | IC50 | = | 450.0 | nM | 6.35 |