Assay Detail
Binding
CHEMBL663403
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Inhibition of cyclin-dependent kinase 1-cyclin B
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.80 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430653 | — | — | 1 | 8.40 |
| CHEMBL328406 | — | — | 1 | 8.15 |
| CHEMBL420463 | — | — | 1 | 8.00 |
| CHEMBL100012 | — | — | 1 | 8.00 |
| CHEMBL318564 | — | — | 1 | 7.92 |
| CHEMBL317953 | — | — | 1 | 7.75 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.52 |
| CHEMBL295136 | — | — | 1 | 7.40 |
| CHEMBL103714 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430653 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL328406 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL420463 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL100012 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL318564 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL317953 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL295136 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL103714 | — | IC50 | = | 80.0 | nM | 7.10 |