Assay Detail
Binding
CHEMBL663404
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Inhibitory concentration against CDK1/cyclin B was determined
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.67 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.52 |
| CHEMBL14619 | SQ-67563 | — | 1 | 6.82 |
| CHEMBL418540 | — | — | 1 | 6.66 |
| CHEMBL279405 | — | — | 1 | 6.62 |
| CHEMBL14327 | — | — | 1 | 6.51 |
| CHEMBL277795 | — | — | 1 | 6.51 |
| CHEMBL14593 | — | — | 1 | 6.46 |
| CHEMBL279590 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL14619 | SQ-67563 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL418540 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL279405 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL14327 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL277795 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL14593 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL279590 | — | IC50 | = | 600.0 | nM | 6.22 |