Assay Detail
Binding
CHEMBL663408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against human Coagulation factor Xa (fXa)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
PRO_SELECT: combining structure-based drug design and array-based chemistry for rapid lead discovery. 2. The development of a series of highly potent and selective factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.21 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20240 | YM-60828 | — | 1 | 8.64 |
| CHEMBL283765 | — | — | 1 | 7.80 |
| CHEMBL20733 | — | — | 1 | 7.58 |
| CHEMBL19902 | DX-9065A | — | 1 | 7.39 |
| CHEMBL20936 | BENZAMIDINE | — | 1 | 6.70 |
| CHEMBL417827 | — | — | 1 | 6.66 |
| CHEMBL20825 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20240 | YM-60828 | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL283765 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL20733 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL19902 | DX-9065A | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL20936 | BENZAMIDINE | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL417827 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL20825 | — | Ki | = | 2000.0 | nM | 5.70 |