Assay Detail
Functional
CHEMBL663520
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity for Corticotropin releasing factor receptor 1
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.75 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10154 | — | — | 1 | 8.70 |
| CHEMBL9946 | CP-154526 | — | 1 | 8.57 |
| CHEMBL9633 | — | — | 1 | 8.46 |
| CHEMBL10504 | — | — | 1 | 8.43 |
| CHEMBL10082 | — | — | 1 | 8.26 |
| CHEMBL273839 | — | — | 1 | 8.01 |
| CHEMBL276263 | — | — | 1 | 7.67 |
| CHEMBL10080 | — | — | 1 | 7.64 |
| CHEMBL10142 | — | — | 1 | 7.49 |
| CHEMBL10174 | — | — | 1 | 7.48 |
| CHEMBL10091 | — | — | 1 | 7.22 |
| CHEMBL10090 | — | — | 1 | 7.02 |
| CHEMBL10315 | — | — | 1 | 6.78 |
| CHEMBL10279 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10154 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL9946 | CP-154526 | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL9633 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL10504 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL10082 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL273839 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL276263 | — | Ki | = | 21.4 | nM | 7.67 |
| CHEMBL10080 | — | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL10142 | — | Ki | = | 32.3 | nM | 7.49 |
| CHEMBL10174 | — | Ki | = | 33.4 | nM | 7.48 |
| CHEMBL10091 | — | Ki | = | 60.3 | nM | 7.22 |
| CHEMBL10090 | — | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL10315 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL10279 | — | Ki | = | 202.0 | nM | 6.70 |